I have set up customized installations of Orbiter (for example, one specifically dedicated to Edwards AFB and the "X" series planes) with customized base configurations,etc and saved the whole kit and kaboodle to a disc many times over the years without any issues (doing so prevents incompatibility issues between addons).
However, DON'T try to "install" it from the disc as you would new software! Orbiter does not write anything to your registry (I'm speaking about previous incarnations of Orbiter as I currently have no experience with the latest version). Simply copy the files on the disc to a folder on your drive and everything should work...including installed addons. The exception being OrbiterSound. This I have always had to actually "install" to the same folder to get it working so I add the compressed file to each disc I make.
I have discs dedicated to the aforementioned "X" planes, Mercury & Gemini, AMSO and the Shuttle series (which come to think of it, I should probably update!). Made some nice disc art and jewel cases to keep 'em in too. When I'm done flying an installation, I can simply delete it from the drive without losing my customizations. If I make changes I want to keep, I just burn another disc.
Saves drive space AND a whole lot of headaches (for me anyway).
As mentioned in the previous thread, since I am only putting these installations back onto the machine they were created with, dll incompatibilities are not an issue. If you're trying to transfer them to another machine (I have only done this twice, but it's capabilities exceeded those of my PC), you may need to do a fresh install of Orbiter and once you've established that it is working correctly, drop the files saved to disc (except the executable or "launch" icon...you will want to use the one from the fresh installation) on it.