Well for one difference between centrifugal gravity and mass gravity.. you have no torque.
With the torque removed when you return to earth.. You might walk lopsided and kinked for a while!
1: That assumes that you will be returning to earth in the first place.
2: It comes right back to the fact that the engineering tolerances for torque and other forces on the human body are easily testable.
In either case, the argument that we can't do long term space travel because we don't have the technology to compress a planet sized mass into a manageable volume is so farcical that it barely warrants a response.
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