http://www.aquiziam.com/end_of_the_world_predictions.html (see number "10." which is at the bottom of the article)
For my hypotesis I suppose that the asteroid will not bring any radioactive contamination (actually hope not)
500 Kilometer Asteroid Hypothesis:
If I knew that would happen and didn't trust in any agency or organization (including the government), plus I could use all money/resources I would need (for such improbable scenario this shouldn't be said stupid), I'd dig 2 kilometers into Northen or Center Tibete (*) and get Svalbard and other genetic/information vaults into the Flak-style-bunker that would be built there. Better also bring some 50 or more people. I doubt that the any impact would damage severely the installations unless the mountains were directly hit. The worst would be to get out of the "BOL" because probably the exit would have been put down.
Another idea was to do this on Mars or the Moon, but it's not reliable with nowdays capacities.
Even another idea! Because no one cares anymore with having electricity or power (highly doubtable I know...) every powerplant would join power to antennas all over the world in strategic positions that would send the information/genetic sequences into all the universe creating something like the Mother of All Omnidirectional Radio Emmiters: luckily there's an alien race that likes to preserve all biodiversity out there and re-create us.
Realistic Asteroid Hypothesis (about 10 Kilometres):
Know where is the Asteroid is going to hit: if the place is nice for my plan, I'd run to Cobber Pedy and build some controlled atmosphere environment in some cave so the climatic changes don't starve me. That's probably the worst that would happen in most of the world, thus (I'm not sure about this one) I think that Cobber Pedy is high enough so that sea level risings wouldn't affect it. In the case of high albedo caused ice age, we could easily move to Darwin because deserts would be gone probably.
NOTES: (*) I don't like downright Himalayas because it sits over a continental border that would probably burst with the pressure.