Make sure you have selected a hardware render device in the "Video" tab of the Orbiter Launchpad dialog (for example "Direct3D HAL T&L"). Avoid the much slower software devices, such as "RGB Emulation". If possible, use a hardware transform and lighting (T&L) device.
Apart from that, all the usual advice for performance-critical simulations applies: Quit other programs running simultaneously (either in the foreground, or as background jobs). On computers with low-end graphics run Orbiter in fullscreen mode, use a lower screen resolution and lower colour depth (16 bit). Reduce the level of "eye-candy" by turning off the options under the "Visual effects" tab of the Orbiter Launchpad.