OT question, what would be needed to make the Enterprise spaceworthy?
The reason Enterprise was never fitted for spaceflight was because during the approach and landing tests, engineers at the factory realized that changes had to be made to the airframe before launching it.
Columbia was still under construction, so it wasn't too expensive to fix it. Enterprise, on the other hand, was a complete airframe, and to make the required changes would've required disassembling the airframe and sending wings and other subassemblies back to vendors to be upgraded to the new specs. It was found to be cheaper to upgrade a structural test article, STA-099, which became OV-099 (Challenger).
So, the answer to your question is that Enterprise would have to be taken apart and her frame fixed up to spec. This was considered a second time after the Challenger wreck.
After that, you install all the usual systems a space-worthy orbiter gets, engines, heat shield, hydraulics, APUs, avionics, etc.
In a fictional space shuttle program based on original plans, Enterprise would've been contructed to the proper spec in the first place, and wouldn't have needed such an expensive rebuild after the ALT. Just install the space-rated subsystems and roll her back out next to Columbia.