I would include the Soyuz TM, TMA and TMA-Mx upgrades as well there. While never a revolution, it was quite an evolution since 1981: Kurs docking system, glass cockpit, digital avionics, new communication systems, new solar arrays, meteorite shields, different TCS, black box....
Soyuz saw quite some changes since the Soyuz-T model flying in 1981. It might look superficially the same since the 1970s, but it saw many changes, some changes big enough to include unmanned test flights in the program.
The last new manned spacecraft was Shenzhou.