"familiar" is a bit optimistic here
But, yes I did some work on interfacing Lua and Orbiter-API.
Running a Lua script in parallel should be no problem (a vessel and the script that should run in one scenario).
But I am not sure whether it is convenient to get vessel specific information from the Spacecraft.dll- rsp. VesselBuilder-vessel.
All the information the script can get are "sqeezed" through the vessel-API calls.
Any specific information from Spacecraft.dll or VesselBuilder vessels are not implemented (yet).
The coders of those DLLs have to provide the Lua interface DLLs for that to happen.
If the information provided via the standard Orbiter-API is enough however, I see no problem.