OK, so what makes you think, you can do more science with Orion?
Remember: The Vikings already reached newfoundland in about 1100 AD, but you don't read about their exploits much in the history books. Why? Because their own infrastructure collapsed early. They did not plan to go there, they just went for new places to settle, and so, they did not care about having solid outposts on their way.
Constellation has many similarities with the failure of the vikings. The program does not plan a infrastructure, which can be used for later missions - it is already at it's limit with the lunar landing, will need further growth of the rocket for even establishing a lunar outpost and the budget does not even dare to say, how to supply such a base. Between a few flags and footprints and the lunar science outpost, you have the bubble "Something magical happens here". How should NASA afford launching more material to the lunar outpost, when their own lunar landing concept already needs two heavy rocket launches. Not rockets for the everyday business of Earth orbit - special designed heavy rockets. Increasing the launch rates for a lunar base will become very expensive with the current NASA plan, unless something magical happens.
That's not how you do science - that's how you do a big show. For science you want just one thing: Launch as many scientific payloads and scientists to the places as you can justify for the costs. Such a program as constellation will be always on the edge for getting terminated by costing too much until it returns something useful.
You need to develop in many fast small steps, if you want to ensure a constant high funding. Be able to react to new developments, and don't fall too deep, when something goes wrong (which is allowed to happen in science). If the first constellation landings don't deliver much more scientific results as a unmanned rover, or worse, no new results, the program will get terminated to the last point that worked.
That will be very likely LEO - at very high costs again. Go directly back to the start.
And don't think SpaceX & Co will make LEO access cheaper from their own in the mean time. Who does not learn from the errors of the past is bound to repeat them.
I hope we will get a follow-on station to the ISS soon. It is only about a decade until the ISS retires and we still have no clue on what to do next in LEO. I would prefer, we finally work on developing robust technologies. Have a standard system for space station modules and space station vehicles, which is open for all nations and companies. Build one or many hubs in LEO and transport bulk material to outer space from there, having at least one launch per week.